Chinese Heparin Seized by Federal Marshals

Months after the heparin contamination scare, US Marshalls seized lots of heparin from an Ohio plant. Federal marshalls seized 11 lots from Celsus Laboratories located in Cincinnati Ohio. Five of the lots seized Thursday were heparin sodium active pharmaceutical ingredient, used in finished drug products. Six were heparin lithium, used in medical devices, the agency said.
The contaminated heparin has been linked to counterfeited heparin manufactured in China. The lots were contaminated with over-sulfated chondroitin sulfate (OSCS), a substance that mimics heparin’s anti-clotting activity. The contaminated heparin caused serious adverse effects earlier this year including nausea, vomiting, shortness of breath, a severe drop in blood pressure, and in some cases, death.
Celsus Laboratories had quarantined the suspected heparin product since learning of the contamination on March 8th but the FDA remained concerned that Celsus practices were insufficient to protect the general public from being exposed to the contaminated heparin.