In spite of sales that top $10 billion a year, a recent study has found that Haldol and Risperdal have no effect in curbing aggressive behavior of intellectually challenged individuals. In fact, placebos actually fared better than the two highly marketed drugs. Treating aggressive behavior with Haldol and Risperdal is considered off-label usage. Doctors are allowed to determine how and when to treat patients, including using medications for off-label use. However, the problem arises when the pharmaceutical companies begin to promote off-label usage in their marketing campaigns. Risperdal and Haldol have been approved for treatment of schizophrenia but have been used off-label to treat aggressive behavior, depression, and attention deficit disorder.